We noticed that the number of splicing factors differentially expressed in cancer, as evaluated by SAGE, was incorrectly reported in Table 1 of our original manuscript. A corrected version of Table 1 is presented below. We would like to modify two paragraphs in the Results section. In the first paragraph of page 516, one should read “A fraction of all splicing factors showed a different level of expression (>3-fold difference) between normal tissues and their tumor counterparts. The number of differentially expressed genes for breast, prostate, brain and colon were 32 (22%), 37 (25%), 12 (08%) and 42 (29%), respectively. This level of differential expression was significant for brain as evaluated by 1000 simulations of 145 randomly taken genes (32 ± 4.9, 32 ± 4.9, 27 ± 4.6 and 42 ± 5.4 random genes differentially expressed in breast, prostate, brain and colon, respectively)”. In the second paragraph of page 516, one should read “Most of the differentially expressed factors in brain (11 - 91%), colon (33 - 78%) and breast (26 - 81%) were up-regulated in tumors. However this trend did not exist for prostate in which only 16 (43%) splicing factors were up-regulated in tumors”. We would like also to stress that the apparent accordance between SAGE and microarray data is much weaker with the data presented in the corrected Table 1.
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