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Review
Escherichia coli as a model system to study DNA repair genes of eukaryotic organisms
Luiz Augusto-Pinto, Carlos Gustavo Regis da Silva, Débora de Oliveira Lopes,
Alice Machado-Silva and Carlos Renato Machado
Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais,
30161-970 Belo Horizonte, MG, Brasil
Corresponding author: C.R. Machado
E-mail: crmachad@mono.icb.ufmg.br
Genet. Mol. Res. 2 (1): 77-91 (2003)
Received November 27, 2002
Published March 31, 2003

ABSTRACT. The bacteria Escherichia coli has been widely employed in studies of eukaryotic DNA repair genes. Several eukaryotic genes have been cloned by functional complementation of mutant lineages of E. coli. We examined the similarities and differences among bacterial and eukaryotic DNA repair systems. Based on these data, we examined tools used for gene cloning and functional studies of DNA repair in eukaryotes, using this bacterial system as a model.

Key words: DNA repair, Functional complementation, Escherichia coli

 

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